St. Louis Community College

Clinical Laboratory Technology



INTERNET LESSON PLAN NUMBER 2

UNIT - Molecular Techniques

SCOPE OF UNIT:

Review nucleic acid structure and function. Relate the tools of DNA analysis to include the use of the Internet. Use molecular techniques and Internet databases to analyze genetic material.

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TITLE OF LESSON: Review of DNA Structure and Function

LESSON OBJECTIVE: The student should be able to:

  1. Examine the structure of DNA and RNA

  2. Picture DNA participating in replication, transcription, and translation.

  3. Relate the central dogma of molecular biology.

  4. Determine the effect of a change in base sequence on protein synthesis.

OVERVIEW:

The area of molecular biology is rapidly expanding our knowledge of genes and their expression. Projects are underway, worldwide, to map the human genome as well as the genome of bacteria, animals and plants. This information will be used to develop future diagnostic tests and medical treatments.

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MATERIALS:

PROCEDURES:

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  1. Ask students to read the introduction of the Primer On Molecular Genetics.

    URL: http://www.ornl.gov/TechResources/Human_Genome/publicat/primer2001/1.html

  2. Look at these graphic gallery pages for images of DNA.

    Access Excellence
    Structure of DNA
    URL: http://www.accessexcellence.org/AB/GG/structure.html
    DNA Molecule - 2 views
    URL: http://www.accessexcellence.org/AB/GG/dna_molecule.html
    DNA Replicating Itself
    URL: http://www.accessexcellence.org/AB/GG/dna_replicating.html
    DNA and RNA
    URL: http://www.accessexcellence.org/AB/GG/rna.html


  3. Learn about the central dogma of molecular biology by reading and viewing images at this site.

    Access Excellence
    Dogma, DNA, and Enzymes
    URL: http://www.accessexcellence.org/AB/BC/Dogma_DNA_and_Enzymes.html
    Central Dogma of Molecular Biology
    URL: http://www.accessexcellence.org/AB/GG/central.html
    Protein Synthesis
    URL: http://www.accessexcellence.org/AB/GG/protein_synthesis.html


  4. Do the DNA Dry Lab Activity. The Genetic Code is available at this site:

    URL: http://psyche.uthct.edu/shaun/SBlack/geneticd.html

  5. Answer questions and participate in discussion.

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INTERACTION ITEMS:

  1. How can our knowledge of previous base sequences translate to knowledge of gene function?

  2. How can our previous knowledge of protein function translate to gene function?

  3. In the DNA dry lab activity, which base substitution or addition will effect protein function? Will not effect protein function?

CLASSROOM, LABORATORY, OR OTHER ACTIVITIES

Complete the DNA dry lab activity sheet.

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EVALUATION:

Evaluate the Dry DNA Lab Activity Sheet for accuracy and completeness.

© Karen M. Kiser 1998


St. Louis Community College at Forest Park
Karen M. Kiser MA MT(ASCP), PBT
Emeritus Professor
Clinical Laboratory Technology/Phlebotomy
St. Louis, MO USA

Updated January 1, 2008

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