Clinical Laboratory Technology

INTERNET LESSON PLAN NUMBER 2

UNIT - Molecular Techniques

SCOPE OF UNIT:

Top Objectives Overview Materials Procedures Questions Activities Evaluation

TITLE OF LESSON: Review of DNA Structure and Function

LESSON OBJECTIVE: The student should be able to:

1. Examine the structure of DNA and RNA
   
   
2. Picture DNA participating in replication, transcription, and translation.
   
   
3. Relate the central dogma of molecular biology.
   
   
4. Determine the effect of a change in base sequence on protein synthesis.

OVERVIEW:

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MATERIALS:

• DNA Dry Lab Activity Sheet. Available at Access Excellence: DNA Dry Lab at
  
  URL: http://www.accessexcellence.org/AE/AEC/AEF/1995/offner_dna.html
  
  
• Genetic Code. The Genetic Code is available at this site:
  
  URL: http://psyche.uthct.edu/shaun/SBlack/geneticd.html
  
  
• Computer with Internet access

PROCEDURES:

Top Objectives Overview Materials Procedures Questions Activities Evaluation

1. Ask students to read the introduction of the Primer On Molecular Genetics.
   
   URL: http://www.ornl.gov/TechResources/Human_Genome/publicat/primer2001/1.html
   
   
2. Look at these graphic gallery pages for images of DNA.
   
   

   Access Excellence

   Structure of DNA
   URL: http://www.accessexcellence.org/AB/GG/structure.html
   DNA Molecule - 2 views
   URL: http://www.accessexcellence.org/AB/GG/dna_molecule.html
   DNA Replicating Itself
   URL: http://www.accessexcellence.org/AB/GG/dna_replicating.html
   DNA and RNA
   URL: http://www.accessexcellence.org/AB/GG/rna.html

   
   
   
3. Learn about the central dogma of molecular biology by reading and viewing images at this site.
   
   

   Access Excellence

   Dogma, DNA, and Enzymes
   URL: http://www.accessexcellence.org/AB/BC/Dogma_DNA_and_Enzymes.html
   Central Dogma of Molecular Biology
   URL: http://www.accessexcellence.org/AB/GG/central.html
   Protein Synthesis
   URL: http://www.accessexcellence.org/AB/GG/protein_synthesis.html

   
   
   
4. Do the DNA Dry Lab Activity. The Genetic Code is available at this site:
   
   URL: http://psyche.uthct.edu/shaun/SBlack/geneticd.html
   
   
5. Answer questions and participate in discussion.

Top Objectives Overview Materials Procedures Questions Activities Evaluation

INTERACTION ITEMS:

1. How can our knowledge of previous base sequences translate to knowledge of gene function?
   
   
2. How can our previous knowledge of protein function translate to gene function?
   
   
3. In the DNA dry lab activity, which base substitution or addition will effect protein function? Will not effect protein function?

CLASSROOM, LABORATORY, OR OTHER ACTIVITIES

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EVALUATION:

Karen M. Kiser MA MT(ASCP), PBT
Emeritus Professor
Clinical Laboratory Technology/Phlebotomy
St. Louis, MO USA

Updated January 1, 2008

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